En 
繁
简
Drug discovery
Drug discovery

Drug discovery

Dr WONG Hoi Leong Xavier

Dr WONG Hoi Leong Xavier

Email: xavierwong@hkbu.edu.hk

Website: https://scholars.hkbu.edu.hk/en/persons/XAVIERWONG

Dr WONG Hoi Leong Xavier
Associate Professor, Teaching and Research Division

Dr. H. L. X. WONG graduated with B.Sc. in 2009 and then received his PhD degree from Department of Biochemistry at the University of Hong Kong in 2013. After receiving postdoctoral trainings in both HKU and CUHK, he joined School of Chinese Medicine at Hong Kong Baptist University as a Research Assistant Professor in late 2016 and became a tenure-track Assistant Professor in 2020.

Dr. Wong is particularly interested in understanding how pericellular proteolysis is linked to intracellular signaling in a timely and spatially controlled manner to coordinate the key cellular functions. We demonstrate for the first time that MMPs and ADAMs, two key families of proteases responsible for extracellular matrix remodeling, serve as critical regulators for multiple signaling cascades including FGFR, Notch and VEGF signaling pathways. Currently, we are also focusing on delineating cellular and molecular mechanisms that regulate the transfer of stem cells from the quiescent niche to the proliferative niche in both physiological and pathological processes, such as functional gastrointestinal diseases and colorectal cancer. His work has been published in internationally renowned journals like Developmental Cell, Nature Communications, The EMBO Journal, Microbiome and Cell Death & Disease.

+ More Information
  • Extracellular matrix remodeling in regulation of development and diseases
  • Stem cell renewal and differentiation in development and diseases
  • Potential benefits of Chinese herbal medicine in the treatment of metabolic diseases
  • Citations: 635
  • h-index: 12
  • i10-index: 14

Guo X, Cao J, Wu J, Huang J, Asthana P, Wong SKK, Gurung S, Zhang Y, Wang S, Kwan HY, Lyu A, Chan KM, Huang JD, Zhou Z, Bian ZX, Yuan S, Wong HLX. (2022) Control of SARS-CoV-2 infection by MT1-MMP-mediated shedding of ACE2. Nature Communications (in press) [Impact factor: 17.694]

Zhai L, Huang C, Ning Z, Zhang Y, Zhuang M, Yang W, Wang X, Zhang EL, Xiao H, Zhao L, Lam YY, Chow CFW, Huang J, Yuan S, Chan KM, Yuan CS, Lau JYN, Wong HLX+ (co-correspondence), Bian Z+. (2022) Ruminococcus gnavus plays a pathogenic role in diarrhea-predominant irritable bowel syndrome by increasing serotonin biosynthesis. Cell Host & Microbe [Impact factor: 31.316]

Guo X, Asthana P, Zhang S, Gurung S, Wong SKK, Fallah S, Chow CFW, Che S, Zhai L, Wang Z, Xin G, Jiang Z, Wu J, Zhang Y, Wu X, Xu K, Lin CY, Kwan HY, Lyu A, Zhou Z, Bian Z, Wong HLX. (2022) Regulation of age-associated insulin resistance by MT1-MMP-mediated cleavage of Insulin Receptor. Nature Communications 13, 3749 [Impact factor: 17.694]

Chow, C. F. W., X. Guo, P. Asthana, S. Zhang, S. K. K. Wong, S. Fallah, S. Che, S. Gurung, Z. Wang, K. B. Lee, X. Ge, S. Yuan, H. Xu, J. P. K. Ip, Z. Jiang, L. Zhai, J. Wu, Y. Zhang, A. K. Mahato, M. Saarma, C. Y. Lin, H. Y. Kwan, T. Huang, A. Lyu, Z. Zhou, Z. X. Bian, Wong HLX (2022) Body weight regulation via MT1-MMP-mediated cleavage of GFRAL. Nature Metabolism 4, 203-212 [Impact factor: 19.865]

Wong HLX, Qin H, Tsang SW, Zuo X, Che S, Chow CFW, Li X. Xiao HT, Zhao L, Huang T, Lin CY, Kwan HY, Yang T, Longo FM, Lyu A, Bian Z (2019) Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling. Nature Communications 10(1):1745 [Impact factor: 17.694]

Back