Drug discovery
- Associate Professor, Teaching and Research Division
- Vincent V. C. Woo Endowed Associate Professor in Chinese Medicine
Biography 
Dr. Cheung is a local trained scientist. He obtained his Bachelor Degree from The Hong Kong Polytechnic University in 1999 and PhD in Physiology from The Chinese University of Hong Kong in 2004. After that, he pursued his postdoctoral training in electrophysiology and calcium signaling at The University of Pennsylvania (Philadelphia, PA, USA) under the supervision of Prof. Kevin Foskett (2004-2010).
In 2010, He took up the Assistant Professor position at the Department of Physiology, University of Hong Kong and joined the School of Chinese Medicine, Hong Kong Baptist University in 2017 as the Associate Professor. Dr.Cheung's research focuses on the structure/function of ion channels and their roles in disease pathogenesis, particularly in the Alzheimer's disease. His work has been published in several top-ranked journals including Neuron, Cell, PNAS and Science Signaling.
+ More InformationResearch Interests
- Structure function of intracellular calcium release channels (inositol trisphosphate receptors, ryanodine receptors and two-pore channel) and their roles in health and disease.
- Molecular mechanisms for Alzheimer's disease pathogenesis (calcium disruption and neuronal autophagy)
- Development of pharmacological compounds from Chinese medicine for Alzheimer's disease therapy.
Google Scholar (Feb 1, 2023)
- Citations: 14,466
- h-index: 31
- i10-index: 56
Selected Publications
Tong CK, Lee SK, Cheng WH, Lai KO, Foskett JK and Cheung KH. (2016) Familial Alzheimer's disease-associated presenilin 1 mutants promote g-secretase cleavage of STIM1 to impair store-operated Ca2+ entry. Sci. Signal. 9:ra89. Corresponding author. News in Alzforum.org.
Lee SK, Tong CK,Cheng WH, Hung CH and Cheung KH. (2016) Characterization of two-pore channel 2 by nuclear membrane electrophysiology. Sci Rep 6: 2028 Corresponding author.
Wang Q, Guo W, Hao B, Shi X, Lu Y, Wong CWM, Ma V WS, Yip TTC, Au JSK, Cheung KH, Wu W, Li GR and Yue J (2016). Mechanistic study of TRPM2-Ca2+-CAMK2-BECN1 signaling in oxidative stress induced autophagy inhibition. Autophagy 12: 1340-1354.
Ullah G, Cheung KH, Toglia P, and Mak D-OD (2015). Analysing and quantifying the gain-of-function enhancement of IP3 receptor gating by familial Alzherimer's disease-causing mutations in presenilins. PLoS Comput. Biol. 11:e1004529.
Mak DO, Vais H, Cheung KH, and Foskett JK. (2013) Patch-clamp electrophysiology of intracellular Ca2+ channels. Cold Spring Harb Protoc 2013(9):787-797.