Grant Information
系统医学与健康以整体中医观点和系统生物学方法为基础来解决健康问题。该研究所开展的研究将涉及和整合来自分子、细胞的数据，以及对相互作用节点的结构和动力学的研究，形成多维矩阵的多个层面的网络，包括分子、细胞、器官、人、家庭、社区、社会和环境。我们提出了一种整体方法，鼓励研究人员、医疗保健教育工作者、中医从业者、临床医生和医疗保健领导者考虑以更加系统化的方式看待个人（作为一个受环境影响的复杂生物系统）。汇总后，此类个人信息可以更好地解释人口多样性（和人口医学），从而有助于为所有人实现更准确的诊断和有效的治疗结果。
Project Ref. No. | Title | PI | Funding Source(s) | |
T12-201/20-R | Aptamer Molecular Insight & Translational Therapeutics | Prof. LYU Aiping | TRS/RGC
| |
12102722 | Development of combination therapy using a mCRP aptamer and Leflunomide for precision medicine-based rheumatoid arthritis treatment | Prof. LYU Aiping | GRF/RGC | |
2020B1212030006 | Guandong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research
| Prof. LYU Aiping | GDSTC | |
| Dysregulated Host - Gut Microbiota Co-Metabolism in Metabolic Associated Fatty Liver Disease | Prof. JIA Wei | RGC | ||
12100323 | Investigation of abdominal pain management in diarrhea-predominant irritable bowel syndrome via short- chain fatty acids/GLP-1 axis | Prof. BIAN Zhaoxiang | GRF/RGC | |
12102223 | Macrophagic sclerostin loop2-ApoER2 interaction participates in the suppressive effect of sclerostin on atherosclerosis | Prof. ZHANG Ge | GRF/RGC | |
12101022 | Impairment of autophagy-lysosomal pathway in Parkinson's disease: Novel roles of HMGB1-TFEB interplay and therapeutic implication of Chinese medicine compounds | Prof. LI Min | GRF/RGC | |
| 09203776 | Natural small molecule Isorhamnetin and its optimized derivatives for Parkinson’s disease treatment by targeting TFEB-mediated autophagy | Prof. LI Min | HMRF | |
12101322 | Key player in the bone-marrow protection of orally-administrated Astragalus polysaccharide RAP after entering Peyer’s patches | Prof. HAN Quanbin Simon | GRF/RGC | |
12101123 | Radix Astragali polysaccharide RAP: an ideal intestinal M cell-targeted oral vaccine carrier and immunostimulant? | Prof. HAN Quanbin Simon | GRF/RGC | |
| 2023A1515011811 | Exploring the mechanism of ARF1/MAP3K-mediated liver fibrosis: Role of adipocyte-derived small extracellular vesicles | Dr KWAN Hiu Yee | Guangdong Province Natural Science Foundation | |
| 08193596 | WNT974 and artesunate exhibit synergy in inhibiting colorectal cancer growth by increasing KRAS protein degradation | Dr KWAN Hiu Yee | HMRF | |
| 2021Szvup131 | Effect of obesity on the protein profiles in the adipocyte-derived small extracellular vesicles | Dr KWAN Hiu Yee | Shenzhen Virtual University Park Special Fund Project | |
| 2021A1515010655 | Exploring the role of hERG/HIF-1 signaling pathway in overweight and obese metastatic CRC patients with resistance to anti-VEGF therapy | Dr KWAN Hiu Yee | Guangdong Province Natural Science Foundation | |
12102923 | Elucidating the role of TRPM7 chanzyme and its therapeutic potential in neuroinflammation of Alzheimer’s disease | Dr. CHEUNG King Ho | GRF/RGC | |
12100321 | Unravelling the pathogenic role of lysosomal TPC2 Ca2+ channel in Alzheimer’s disease | Dr. CHEUNG King Ho | GRF/RGC | |
2023A1515010641 | 中藥小分子線粒體自噬激活劑作為緩解阿爾茨海默症潛在治療藥物的研究 | Dr. CHEUNG King Ho | GDSTC | |
20212841 | Investigate the therapeutic potential of targeting TRPM7 by carvacrol to mitigate Alzheimer's disease-associated neuroinflammation | Dr. CHEUNG King Ho | HMRF/FHB | |
GHX/133/20S | Computational Models for Health Management System using Multi-Source Data | Dr. ZHANG Lu | TCFS/ITC | |
2021A1515012226 | A graph-based diploid assembly algorithm for detecting structural variants on linked-read sequencing | Dr. ZHANG Lu | GDNSF
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22104123 | Investigating the regulatory role of phenethylamine for serotonin reuptake in the pathogenesis of diarrhea-predominant Irritable Bowel Syndrome | Dr. WONG Hoi Leong Xavier | ECS/RGC | |
| Dissecting the Therapeutic Role of 3A2 Antibody for the Treatment of Obesity and Type 2 Diabetes | Dr. WONG Hoi Leong Xavier | ITF/ITC | |
22102823 | Blocking exosome release from atrophic skeletal muscle to strengthen bone: a novel therapeutic strategy for muscle atrophy-associated bone loss? | Dr. LIU Jin | ECS/RGC | |
12102322 | The role of the interactions between N domain and Linker 2 of DKK1 in modulating the immunosuppressive tumor microenvironment mediated by DKK1 C domain | Dr. YU Yuanyuan | GRF/RGC | |
| Targeting sclerostin loop3 to promote bone formation with low cardiovascular risk in animal models | Dr. YU Yuanyuan | GRF/RGC | |
12201023 | Reducing uncertainties in predictions of future air pollution, heat extremes, and associated health risks in Asia with dynamical downscaling and machine learning | Dr. GAO Meng | GRF | |
12300823 | Dynamic regulation of p53 signaling and chemoresistance in three-dimensional (3D) cancer models | Prof. SHI Jue | GRF/RGC | |
RFS2021-2S01 | Antitumor dynamics of Natural Killer cell and its response to immune checkpoint inhibitors in 3D tumor organoid models | Prof. SHI Jue | RFS/RGC | |
12302421 | Dynamic Behaviors and Strategies of Natural Killer Cell Chemotaxis towards Distinct Cancer Targets | Prof. SHI Jue | GRF/RGC | |
12275229
| Organizational principles of the human microbiome and their applications in fecal microbiota transplantation --- An ecological and functional network-based study
| Dr. TIAN Liang
| NNSFC | |
C2005-22Y
| A novel TCM-based network pharmacology framework to human diseases and drug-disease relationship
| Dr. TIAN Liang
| RGC
| |
22B2/049A
| Construction of a Traditional Chinese Medicine Diagnostic and Treatment Assistance System for Long COVID Based on Big Data and Artificial Intelligence
| Dr. TIAN Liang
| CMDF
| |